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David Bradley ISSUE #1
September 1999

Beating cancer with soy and clover

Whether or not compounds found in soy and clover could reduce the risk of endometrial cancer is the subject of a clinical trial recently launched by the Center for Women's Health at Cedars-Sinai Medical Center in Los Angeles.

Cell division in the lining of the uterus - the endometrium - is triggered by the female hormone oestrogen during the menstrual cycle and checked by progesterone following menstruation. If the hormone system gets out of control unchecked cell division can eventually lead to cancer.

However, Asian women have a much lower risk of endometrial cancer - one in 100,000 as opposed to 20 in 100,000 for those in the West, hinting that plant compounds - phytoestrogens - in the food they eat may help check the cell division process even if the natural hormones don't. Plants such as soy and clover may be the prime contenders for the role because they contain phytoestrogens known as isoflavones, which have estrogenic properties.

The trial led by Georgina Hale will study whether or not these phytoestrogens counteract the activity of natural oestrogen in triggering cell proliferation. If they do then it implies that turning to a diet rich in phytoestrogens could reduce the risk of endometrial cancer.