One-pot synthesis creates anticancer candidates – Researchers in Germany have developed a simple, rapid and high-yielding cascade synthesis of a collection of polycyclic compounds that resemble indole alkaloid natural products and which interfere with cell division. The compounds could be promising new anticancer drug candidates.
First electronic optical fibers with hydrogenated amorphous silicon are developed – A new chemical technique for depositing a non-crystalline form of silicon into the long, ultra-thin pores of optical fibers has been developed by an international team of scientists in the United States and the United Kingdom. The technique, which is the first of its kind to use high-pressure chemistry for making well-developed films and wires of this particular kind of silicon semiconductor, will help scientists to make more-efficient and more-flexible optical fibers.
MSU chemists become the first to solve an 84-year-old theory – The same principle that causes figure skaters to spin faster as they draw their arms into their bodies has now been used by Michigan State University researchers to understand how molecules move energy around following the absorption of light. In the current issue of Science, MSU chemist Jim McCusker demonstrates for the first time the effect is real and also suggests how scientists could use it to control and predict chemical reaction pathways in general.
New synthetic molecules treat autoimmune disease in mice – A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine.
Scientists Fixate on Ric-8 to Understand Trafficking of Popular Drug Receptor Targets – Half the drugs used today target a single class of proteins – and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health. What you see, what you smell, how you feel – molecules known as G-protein coupled receptors and their prime targets, G proteins, are key to those and many other processes that are ubiquitous in our bodies, and Ric-8 plays a vital role.