Chemical cages, resveratrol and asthma

These are my reactive chemistry links for:

  • Caged molecules – Can you trap two small molecules at the same time in a hollow molecular cavity  and still call them two separate molecules, or is something more bizarre happening in this tiniest of reaction vessels. Chemist Henry Rzepa and his colleagues have tried to find out when those small molecuels are cyclobutadiene and carbon dioxide and the hollow molecule is a calixarene.
  • Paracetamol and childhood asthma – risk uncertain – Children who had reportedly been given more paracetamol (acetaminophen) between five and six years were more likely to have wheeze and asthma symptoms during that same time period than children who were given less. BUT, the analysis cannot show that paracetamol played a role in the development of asthma or wheeze since it is possible that children with these conditions took more paracetamol because they were more often symptomatic.
  • GSK abandons resveratrol – GlaxoSmithKline has reportedly abandoned work on SRT501, or resveratrol, the controversial drug based on the ingredient found in red wine that has been said to reverse the aging process. The news came as no real surprise—the company has been quiet about the compound since May, when it halted a clinical trial of the drug in multiple myeloma after cases of kidney failure occurred. It always struck me as a red herring, as if red wine could actually be healthy. Pah!