One school of thought on how creatine helps slow parkinson’s disease is that creatine increases the available energy for brain nerve cells. This helps prevent the loss of mitochondria and its resulting damage to the nerve cells.

The second idea is that creatine may have a direct effect on the mitochondria which are necessary for the health and survival of the nerve cell. It more or less seems like the more energy a cell has, the better it can protect itself from injury and premature death.