Pumping bacterial toxins

In a previous issue, we discussed early work on Escherichia coli as a proof of principle for understanding how bacterial resistance to antibiotics can emerge. Now, Edward Yu’s team at Iowa State University have taken another step forward in our understanding of this pressing issue by using crystallography to reveal the structure of a protein regulator that controls the expression of the multidrug efflux pump in Mycobacterium tuberculosis.

via TB or not TB: Efflux X-rayed – Ezine – spectroscopyNOW.com.