US chemists have attached polymer chains to a small, robust molecule and used ultrasound to grab the chains and literally pull the molecule apart. The technique can reverse click chemistry reactions, a popular transformation in which simple starting materials are snapped together under mild conditions. Reversing this process, or ‘unclicking’ the components, could be used to activate covalent bonds in a manner that is inaccessible through thermal or photochemical treatments.
My latest news item on Chemistry World:
Sound approach to unclicking click chemistry.