In a previous issue, we discussed early work on Escherichia coli as a proof of principle for understanding how bacterial resistance to antibiotics can emerge. Now, Edward Yu’s team at Iowa State University have taken another step forward in our understanding of this pressing issue by using crystallography to reveal the structure of a protein […]
An interdisciplinary study hinging on X-ray crystallography and nuclear magnetic resonance studies has examined 1000 proteins from more than 40 different human pathogens, including those responsible for plague, anthrax, salmonella, cholera, tuberculosis, leprosy, amoebic dysentery and influenza. Researchers at the Center for Structural Genomics of Infectious Diseases (CSGID) and the Seattle Structural Genomics Center for […]
Drugs used to overcome cancer may also combat antibiotic resistance: McMaster researchers – The pharmaceutical sector has made a big investment in targeting kinases proteins, so there are a lot of compounds and drugs out there that, although they were designed to overcome cancer, they can in fact be looked at with fresh eyes and […]
Scientists Fixate on Ric-8 to Understand Trafficking of Popular Drug Receptor Targets – Half the drugs used today target a single class of proteins – and now scientists have identified an important molecular player critical to the proper workings of those proteins critical to our health. What you see, what you smell, how you feel […]
Biomolecular NMR experts in Germany have discovered how the U2AF protein facilitates the process of splicing used by cells to make the correct template for RNA transcription and the subsequent expression of proteins. More on this in my column on NMR Knowledge Base – The NMR Resource.
‘Unnatural’ chemical allows Salk researchers to watch protein action in brain cells – Researchers at the Salk Institute have been able to genetically incorporate "unnatural" amino acids, such as those emitting green fluorescence, into neural stem cells, which then differentiate into brain neurons with the incandescent "tag" intact. Loudspeakers in your window – Korean scientists […]